MRC General Population Cohort
The rural GPC in Kyamulibwa, southwest Uganda has been followed since 1989 providing longitudinal data and valuable specimens that have helped to describe the HIV epidemic in Africa. The GPC is a long-standing open cohort designed to document trends in the prevalence and incidence of HIV infection and their determinants (behavioural and epidemiological) in a general population in Kalungu district through annual demographic, socio-medical and serological surveys. The cohort remains vital to answer important questions about the changing transmission dynamics in a mixed rural and peri-urban population that reflects the changing patterns of lifestyles and the epidemic in Uganda. It also provides a unique opportunity to understand the differences in the epidemiological drivers and virological patterns between the general population and high-risk cohorts.