Phylogenetics And Networks for Generalised HIV Epidemics in Africa


Botswana Combination Prevention Project (BCPP)


The Botswana Combination Prevention Project (BCPP) is designed to test the hypothesis that implementing an enhanced combination prevention package which includes provision of ART as prevention for HIV-infected individuals with HIV-1 RNA ≥10,000 copies/ml will impact the HIV/AIDS epidemic by significantly reducing population-level, cumulative HIV incidence in a defined geographic area over a period of three years and will be cost-effective.

A cluster randomized trial, the BCPP targets residents in 30 villages and involves over a 100,000 people. Participants receive household visits and services (if needed) that include HIV testing and counseling, antiretroviral treatment, male circumcision, and treatment for prevention of mother-to-child transmission of HIV. Some prevention services are expanded to reach HIV-infected individuals with high viral loads. The goal is to significantly reduce the number of new HIV infections within a community. The BCPP is a collaboration with the Botswana Harvard Partnership, Botswana’s Ministry of Health, and the U.S. Centers for Disease Control and Prevention.

The project is called Ya Tsie in Setswana, the language of Botswana. The name comes from a proverb that roughly translates as “Teamwork bears more fruit than individual effort.”