Phylogenetics And Networks for Generalised HIV Epidemics in Africa


Imperial College

The Department of Infectious Disease Epidemiology (DIDE) at Imperial College London specialises in quantitative epidemiology encompassing mathematical modelling, statistical analysis, and evolutionary epidemiology, to aid the control and treatment of infectious diseases. The Department carries out interdisciplinary research into a wide variety of infectious diseases and pathogens. With a view on HIV and AIDS, DIDE hosts the UNAIDS Epidemiology reference group, the HIV modelling consortium, and is involved in major international collaborations such as the PopART/HPTN071 HIV prevention trial, and PANGEA-HIV.

Researchers at DIDE and the University of Edinburgh are involved in the primary scientific analysis of the data generated by the PANGEA-HIV consortium. Lead by Professor Christophe Fraser (Imperial) and Andrew Leigh-Brown (Edinburgh), the main role of the team is to 

- conduct a methods comparison exercise in order to provide an objective evaluation of currently available phylogenetic tools

- direct and promote further methodological development to address key challenges in measuring, understanding and controlling HIV transmission dynamics of generalised HIV epidemics

- undertake primary analyses of data generated by PANGEA-HIV in collaboration with the participating cohort sites and external research groups.

Key personnel at Imperial:

Professor Christophe Fraser, principal investigator

Dr Oliver Ratmann, research fellow

Dr Anne Cori, affiliated research fellow              

Dr Mike Pickles, affiliated research fellow

Researchers at Imperial College are also involved in the PopART study. Dr Sarah Fidler has experience in HIV treatment studies and in leading international HIV research trials. She is the Co-PI of PopART and of the phylogenetics ancillary study of PopART. The ancillary study of PopART is being led by Prof Christophe Fraser.