PANGEA stands for "Phylogenetics And Networks for Generalised Epidemics in Africa". The overarching goal of the PANGEA consortium is to identify individual and population level factors that drive the epidemic using HIV-1 phylogenetic data, analyse the dynamics of the epidemic, and translate these findings into information that can be used to more effectively target interventions. PANGEA consists of many partners in Africa, Europe and the US.
PANGEA-HIV 2 (Phylogenetics And Networks for Generalised Epidemics in Africa) is a collaboration between scientists from the Africa Health Research Institute (South Africa), Rakai Health Sciences Program (Uganda), Johns Hopkins University (USA), Medical Research Council/Uganda Virus Research Institute (Uganda), Zambart Project (Zambia), London School of Hygiene and Tropical Medicine (UK), Imperial College London (UK), Partners in Prevention Project at the University of Washington (USA), Botswana Harvard AIDS Institute Partnership (Botswana/USA), University of Edinburgh (UK), and the University of Oxford (UK).
Christophe Fraser (PI), Deenan Pillay, Kate Grabowski, Andrew Rambaut
Helen Ayles, Lucie Abeler-Dörner, David Bonsall, Rory Bowden, Max Essex
Sarah Fidler, Christophe Fraser, Kate Grabowski, Tanya Golubchik, Ravindra Gupta
Richard Hayes, Joshua Herbeck, Joseph Kagaayi, Pontiano Kaleebu, Jairam Lingappa,
Vladimir Novitsky, Sikhulile Moyo, Deenan Pillay, Thomas Quinn, Andrew Rambaut, Oliver Ratmann,
Janet Seeley, Deogratius Ssemwanga, Frank Tanser, and Maria Wawer
|Scientific Advisory Board:|
Myron Cohen, Caroline Colijn, Anne Johnson, Peter Geoffrey-Faussett, Musonda Simwinga
PANGEA has been funded in two phases by the Bill & Melinda Gates Foundation. The first phase (2013-2017) establishing the network, obtaining viral sequences and clinical data, and creating a sequence database. Over 13,000 HIV genomes were sequenced during this first phase of the project. The second phase (2017-2021) will will see the generation of more sequences, but mainly focus on analysis.
PANGEA 1 was led by Deenan Pillay, with Andrew Leigh Brown, Christophe Fraser, Paul Kellam and Tulio de Oliveira as members of the executive committee, and Anne Hoppe as project manager. Members of the PANGEA 1 Steering Committee were Myron Cohen, Tulio de Oliveira, Ann Dennis, Max Essex, Sarah Fidler, Daniel Frampton, Christophe Fraser, Richard Hayes, Joshua Herbeck, Anne Hoppe, Pontiano Kaleebu, Paul Kellam, Cissy Kiyo, Andrew Leigh Brown, Jairam Lingappa, Vladimir Novitsky, Nick Paton, Deenan Pillay, Thomas Quinn, Oliver Ratmann, Deogratius Sseemwanga, Frank Tanser, and Maria Wawer. Members of the scientific advisory board were Kevin de Cock, Carl Dieffenbach, Eric Goosby, Simon Hay, Anne Johnson, Stuart Ray, and Christine Wasunna.